Orexigen Therapeutics has just announced that its new weight-loss drug, Contrave, has exceeded the first round of the U.S. Food and Drug Administration’s (FDA) requirements during clinical trials as effective for weight loss. They still are awaiting word if they will meet the FDA’s requirements for safety; however, due to its fat burner and appetite suppressant ingredients, this outlook appears promising.Another FDA approved fat loss supplement is the Alli diet pill.
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Results are in from the clinical trials between people given Contrave and those who were given a placebo. During a one year trial, those who were taking the Contrave diet pill lost an average of 8 percent of their body weight. This equals out to about 17 pounds. Those taking the placebo only lost an average of 1 percent of their body weight. An excellent fat burner!
In order for a weight loss drug to be FDA approved as effective, patients taking the diet pill must lose at least 5 percent of their body weight and at least twice as many people on the drug in the clinical trial should lose 5 percent.
In two clinical trials, between 48 and 56 percent of the people taking Contrave lost more than 5 percent of their body weight. Also, Contrave exceeded expectations in that three times more people lost 5 percent of their body weight, rather than the expected ratio.
Most diet pills work by blocking fat or starches. Contrave works from an entirely different angle. It focuses on the neurological causes of obesity; therefore, it targets your brain to reduce your cravings and suppress appetite.
Recent studies show that this diet pill can reduce metabolic syndrome, which is a combination of risk factors that can increase the risk of obesity, which can lead to heart disease and diabetes.
The other very important aspect that makes Contrave unique is that it is actually a combination drug where it contains two key ingredients that will targets other issues, as well. It contains buproprion (Wellbutrin), which is an anti-depressant medication, and naltrexone, which is used to treat alcohol and opiate addiction.
The verdict is still out on the safety of this diet pill; however, the two key ingredients it contains have been used for other issues for a long time, now. There are some common Contrave side effects that have been reported, which include:
NauseaConstipationHeadacheRise in blood pressureRise in pulse rateThe FDA panel had concerns that people taking Contrave routinely experienced hikes in blood pressure and, less often, in pulse rates. The participants who lost more than 10% of their body weight saw improvements in blood pressure. This was a minority of subjects who attained such a weight loss.
In another study of 3,000 people, where 40 percent dropped out, there were two people who had severe side effects. One person had a gall bladder infection and one person had seizures.
There is still some debate as to whether this diet pill will actually live up to the hype. Some say that while it is better than others on the market, the clinical trials only prove that you will lose a small amount of weight by controlling cravings. Unfortunately, people tend to overeat for other reasons than cravings. Also, some doctors are concerned at its long term effects.
However, many agree that as long as it is proven safe, it is a better alternative to those currently on the market due to its combination ingredients that target other issues.
People tend to live busy lives; therefore, are always looking for an easier way. Contrave has already been proven to be effective and contains other ingredients that can target depression and smoking, which are issues millions of people suffer with. As long as it is proven safe, there is no doubt that Contrave will be the next big diet pill fad.
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1. Written by This e-mail address is being protected from spam bots, you need JavaScript enabled to view it , on 09-12-2010 01:17
It appears that the partial drug bupropion has been used off lable as a weight loss drug in the past by various doctors. Still Contrave does not have the effect of Qnexa. I expect Qnexa will also make it eventually.
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